WHAT IS BIOPRINTING?

Understanding the science behind BIOLIFE4D.

What is bioprinting? For years scientists and engineers have been using 3D printers to create objects out of metals and plastics. The 3D printing industry has become so big, in fact, that over the next few years its projected worth is expected to top $30 billion.

But what if we could print a human organ, ultimately even a human heart? Science has found a way. This is not science fiction. This is science fact. And it’s all done through a process called bioprinting.

By definition, 3D bioprinting is the process of creating cell patterns in a confined space using 3D printing technologies, thereby preserving cell function and viability within the printed construct. In other words, a 3D bioprinter is a highly specialized 3D printer designed to protect living cells during the printing process. Bioprinters are now capable of creating functional biological structures with the potential to one day restore, maintain, improve, and/or replace existing organ function.

Today, advancements in regenerative medicine, adult stem cell biology, additive manufacturing (3D printing) and computing technology have enabled bioprinting to produce human body parts including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures – and even organs.

Everything in the human body is made up of cells, and nature itself has been evolving the capability of programming cells to do specific jobs for millions of years. The human embryo is the best example of this biological manufacturing process. Every cell begins as a stem cell and then is biologically programmed to do a specific job through the natural biologic process inside the body.

3D printed sheets of cells and ECM. C2C12 myoblasts in FRESH printed constructs at 1 and 7 day time points demonstrating that cells spread and proliferate in 3D. Scale bars are 50 µm. Image adapted from Hinton et al, Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels, Science Advances, 1(9), 2015, e1500758

Enter BIOLIFE4D

During the 3D bioprinting process, BIOLIFE4D plans to replicate the same conditions in vitro (outside of the body) as occur naturally in vivo (within the body) while promoting natural biologic processes in an accelerated timeframe and in a manner that allows the cells to be specialized for a desired purpose.

Transformative Benefits of BIOLIFE4D’s 3D Bioprinting Process

Delivering potentially transformative medical benefits, the 3D bioprinting process optimized by BIOLIFE4D could:

Biolife4D Bioprinting

  • Eliminate the rejection of transplanted organs by utilizing a patient’s own cells to produce an organ
  • Eradicate immunosuppressant therapy requirement (and bad side effects) for the patient
  • Provide functionality with capabilities very similar to those in the original organ
  • Decrease waiting time of patients for donated organs
  • Minimize need for organ donors
  • Increase patient longevity without compromising quality of life
  • Allow for patient-specific pharmaceutical testing
  • Substantially reduce the reliance on animal testing for pharmaceutical research and development, and in other industries such as cosmetics
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